Mounjaro (tirzepatide) is a once-weekly injectable medication used for type 2 diabetes management (and more recently, for obesity/weight management also under the brand name Zepbound). The idea of maintenance dosing refers to the ongoing, stable dose a patient continues on long-term after titration (dose-building).

Here’s how it works:

1. Starting and Titration Phase

• Patients usually start at 2.5 mg once weekly for 4 weeks.

• The purpose of this low starting dose is to help the body adjust and reduce gastrointestinal (GI) side effects (nausea, vomiting, diarrhea).

• After 4 weeks, the dose is increased to 5 mg once weekly.

2. Titration to Higher Doses (if needed)

• If additional glucose control (for diabetes) or weight reduction is desired, the dose can be increased in 2.5 mg increments every 4 weeks.

• Available doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg.

3. Maintenance Dose

• The maintenance dose is the dose you stay on long-term once your treatment goals are met and tolerated.

• For type 2 diabetes, the maintenance dose is typically 5 mg, 10 mg, or 15 mg once weekly, depending on individual response and tolerance.

• For obesity/weight management, the maintenance dose may be on the higher end (10 mg or 15 mg) because greater appetite suppression and weight loss are linked to higher doses.

• The right dose varies—some patients do very well at 5 mg, while others need titration up to 15 mg.

4. Key Considerations

• There’s no maximum treatment duration—Mounjaro is meant for chronic, long-term use.

• If side effects occur at a higher dose, patients may stay at a lower, tolerated dose as their maintenance dose.

• Dose adjustments should always be guided by your prescriber, based on glucose control, weight goals, and tolerability.

👉 In short: Maintenance dosing means the ongoing weekly dose you remain on after the titration phase—commonly 5 mg to 15 mg once weekly, tailored to your needs.

NB:For dosage advice particular for your individual needs always seek advice from a medical professional